Fayyaz S. Sutterwala

Biography

The research of Fayyaz Sutterwala, MD, PhD, research focuses on innate immunity and in particular the NLR (nucleotide-binding domain leucine-rich repeat containing receptors) family of molecules that are involved in the regulation of inflammatory and cell death pathways. The members of Sutterwala Laboratory has played an instrumental role in defining the functional role and mechanism of activation of the NLRP3 inflammasome, a multiprotein complex that drives the activation of caspase-1. They were also amongst the first groups to postulate that the NLRP3 inflammasome plays a role in detecting and responding to cellular stress and damage. The lab members are currently working towards further defining the molecular mechanisms by which inflammaosme activation occurs and its role in host defense against a variety of pathogens. They are also interested in how inflammasomes can exacerbate inflammatory responses to sterile inflammatory insults such as ischemia and inhaled environmental pollutants. Education Undergraduate: Washington University, 1992 Medical School: Temple University School of Medicine, 2000 Residency: Yale-New Haven Hospital, 2002 Fellowship: Yale School of Medicine, 2007 Cedars-Sinai Affiliations Department of Biomedical Sciences Lung Institute (Women's Guild Lung Institute) Awards & Activities Review Editor: Frontiers in Immunology, 2015-present Consulting Editor: JCI Insight, 2016-present Section Editor: Journal of Immunology, 2016-present Edward Mallinckrodt, Jr. Foundation Scholar, 2010-13 University of Iowa Presidential Biological Scholars Award, 2007-12 Elected to the American Society for Clinical Investigation, 2012 Central Society for Clinical Research Early Career Development Award, 2011 Pfizer Fellowship in Infectious Diseases, 2006-07

Research Interest

IM/Infectious Diseases