Thomas Lufkin
ProfessorÂÂ
Department of Biology
Clarkson University
United States of America
Biography
Thomas Lufkin is currently working in the Clarkson University as a professor, USA
Research Interest
Our research is in the novel area of Developmental Genomics and Regenerative Medicine with a focus on the molecular mechanisms controlling vertebral column development and an emphasis on early embryogenesis and embryonic stem cell commitment to specific differentiation pathways, but from a novel Systems Biology point of view. We use both mouse and zebrafish as model animals. In particular we are working on understanding the gene regulatory networks (GRNs) that govern normal embryonic development of the vertebral column and intervertebral disc (IVD). We are investigating the role of transcriptional regulators in the restriction of pluripotent embryonic stem cells into specific lineages that in turn comprise functional pre and postnatal vertebral elements with the goal of applying this knowledge to regenerative medicine using patient- specific induced pluripotent stem (iPS) cells and adult mesenchymal stem cells
Publications
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Lim, L.W., S. Shrestha, Y.Z. Or, S.Z. Tan, H.H. Chung, Y. Sun, C.L. Lim, S. Khairuddin, T. Lufkin and V.C. Lin (2016). Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice. Sci Rep, 6: 37568. 10.1038/srep37568
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Sivakamasundari, V., P. Kraus, W. Sun, X. Hu, S.L. Lim, S. Prabhakar and T. Lufkin (2016). A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development. Biol Open. 10.1242/bio.023218
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Kraus, P., R. Yerden, V. Kocsis and T. Lufkin (2017). RNA in situ hybridization characterization of non-enzymatic derived bovine intervertebral disc cell lineages suggests progenitor cell potential. Acta Histochem. 10.1016/j.acthis.2016.12.004
