Bruce D Trapp
Department Chair
Neurosciences
Cleveland Clinic Lerner Research Institute
United States of America
Biography
Our research aims are to obtain a better understanding of cellular/molecular events involved in glial cell development and myelin formation in the central and peripheral nervous systems (CNS and PNS) and to understand how myelin, myelin-forming cells, and axons are destroyed in autoimmune and inherited diseases of myelin
Research Interest
New data about the normal functioning of myelin-forming cells and myelin-axon interactions will help us understand the pathogenic mechanisms involved in permanent neurological disability in human diseases of myelin.
Publications
-
Chen Z, Chen JT, Johnson M, Gossman ZC, Hendrickson M, Sakaie K, Martinez-Rubio C, Gale JT, Trapp BD. (2015) Cuprizone does not induce CNS demyelination in nonhuman primates. Ann Clin Transl Neurol 2:208-13.Â
-
Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. (2016) A mouse model for testing remyelinating therapies. Exp Neurol 283(Pt A):330-340.
-
Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD. (2016) Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol 215(4):531-542.
