Dennis J. Stuehr
Associate Staff
Pathobiology
Cleveland Clinic Lerner Research Institute
United States of America
Biography
Our laboratory studies nitric oxide (NO) biosynthesis in mammals. NO is made by an enzyme named NO synthase, and is involved in many aspects of cell function and disease, including signal transduction in the brain, control of blood pressure and heart rate, gastric motility, oxygen delivery, immunologic destruction of tumor cells and microbes, infertility, impotence, and stroke.
Research Interest
Inflammation; Nitric oxide; Heme transport; Soluble guanylate cyclase; Electron transfer
Publications
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anda K, Haque M, Garcin-Hosfield E, Durra D, Getzoff E, Stuehr DJ. Surface charge interactions of the FMN module govern NO synthase. J Biol Chem 2006 28:36819-27
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Haque M, Panda K, Tejero J, Aulak K, Fadlalla M, Mustovich A, Stuehr DJ. A connecting hinge represses the activity of endothelial NO synthase. PNAS 2007 104:9254-9
