Jonathan D. Smith
Staff
Cellular and Molecular Medicine
Cleveland Clinic Lerner Research Institute
United States of America
Biography
We apply cell/molecular biology, biochemistry, and genetics/genomics to study three areas related to cardiovascular disease.
Research Interest
Atherosclerosis; HDL metabolism; Atrial fibrillation; Genetics; Genomics; eQTL; Gene expression; Reverse cholesterol transport; Dysfunctional HDL; RNAseq; Allelic expression imbalance; ABCA1; Mouse models; Zinc finger nuclease
Publications
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Wang S, Brubaker G, Robinet P, Smith JD, Gulshan K. ORMDL orosomucoid-like proteins are degraded by free cholesterol loading induced autophagy. (2015) Proc Natl Acad Sci USA 112:3728-33.
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ore-Panter SR, Hsu J, Barnard J, Moravec CS, Van Wagoner DR, etal. the PITX2 adjacent noncoding RNA, is expressed in human left atria and regulates PITX2c expression. (2016) Circ Arrhythm Electrophysiol 9:e003197.
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Gulshan K, Brubaker G, Conger H, Wang S, Zhang R, et al.PI(4,5)P2 is translocated by ABCA1 to the cell surface where it mediates apolipoprotein A1 binding and nascent HDL assembly, and it is carried on HDL. (2016) Circ Res 119:827-838.
