Jonathan Mark Brown
Assistant Staff
Cellular and Molecular Medicine
Cleveland Clinic Lerner Research Institute
United States of America
Biography
My research is focused on the interrelationship between lipid metabolism and the development of chronic diseases such as obesity, diabetes, and atherosclerosis. We have three active research programs, and we are always looking for highly motivated young scientists to participate in our multidisciplinary training program.
Research Interest
Lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition.
Publications
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Cantley JL, (2013) CGI-58 knockdown sequesters diacylglycerols in lipid droplets, preventing DAG-mediated PKCε translocation to the plasma membrane and hepatic insulin resistance. Proc. Natl. Acad. Sci USA 110(5): 1869-1874.
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Lord CC, (2012) CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Diabetes 61(2): 355-363.
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Temel (2010) Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metab. 12(1): 96-102.
