Takuya Sakaguchi
Staff
Stem Cell Biology and Regenerative Medicine
Cleveland Clinic Lerner Research Institute
United States of America
Biography
Our laboratory utilizes zebrafish to investigate the pathogenesis of human liver diseases including biliary atresia (BA) and nonalcoholic steatohepatitis (NASH). Through an unbiased genome-wide forward genetic screen, we have isolated new zebrafish mutants that model these human liver diseases.
Research Interest
liver development; organogenesis; regeneration; microenvironment; zebrafish; endothelial cell signaling; cholangiocyte; branching morphogenesis; ROS
Publications
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Dimri M., Bilogan C., Pierce LX., Naegele G., Vasanji A., Gibson l., McClendon A., Tae K., Sakaguchi T.F. (2017) Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepaticbiliary network branching in zebrafish. 144(14):2595-2605
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Nussbaum J.M., Liu L.J., Hasan S.A., Schaub M., McClendon A., Stainier D.Y.R. and Sakaguchi T.F. (2013) Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis. Hepatology, 58(4):1326-1338.
