Thomas A. Hamilton
Department Chair
Stem Cell Biology and Regenerative Medicine
Cleveland Clinic Lerner Research Institute
United States of America
Biography
The diversity of the inflammatory process stems from multiple sources, including the complexity of inflammatory stimuli and cell types, the transmembrane and intracellular signaling processes that occur following stimulation, and the large number of independently regulated genes whose expression is subject to modulation during the process.
Research Interest
Clinical Machine Learning Models; Healthcare Big Data Analytics; Bayesian Inferences with Gaussian Markov Random Field Models; Measurement Error Models; Quantitative Image Data Analysis; Bioinformatics
Publications
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Zhao, C., Datta, S., Mandal, P., Xu, D., and Hamilton, T., Stress sensitive reguation of IFRD1 mRNA decay is mediated by an upstream open reading frame (ORF), J. Biol. Chem. 285: 8552-8562, 2010.
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Datta, S., Novotny, M., Pavicic, P.G., Zhao, C., Herjan, T., Hartupee, J., and Hamilton, T.A., Interleukin 17 regulates CXCL1 mRNA stability via an AUUUA/Tristetraprolin independent sequence, J. Immunol. 184 1484-1491, 2010.
