Janet Sparrow
Professor
Ophthalmic Science and Pathology and Cell Biology
Columbia University
United States of America
Biography
Dr.Sparrow presently working as Professor of Ophthalmic Science and Pathology and Cell Biology, Columbia University withadverse effects of RPE lipofuscin pigments are attributable, at least in part, to their detergent-like structure, their ability to initiate photooxidative processes and in some cases their tendency to undergo pH dependent protonation/deprotonation.
Research Interest
Retina, retinal pigment epithelium, bisretinoid, lipofuscin, retinal degeneration, maculopathy; fundus autofluorescence
Publications
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Secondi R, Kong J, Blonska A, Staurenghi G, Sparrow JR(2012) Fundus autofluorescence findings in a mouse model of retinal detachment. Invest Ophthalmol Vis Sci 53:5190-5197.
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Zhou J, Kim SR, Westlund B, Sparrow JR(2009)Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci 50:1392-1399.
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"Zhou J, Jang YP, Kim SR, Sparrow JR (2006) Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci 103:16182-16187. "
