Professor of Ophthalmic Sciences (in Ophthalmology
Columbia University?Medical Center
United States of America
Gülgün Tezel, MD, is a leading scientist in the field of glaucoma research. Dr. Tezel’s translational research has focused on the molecular mechanisms, biomarkers, and new treatment targets of glaucomatous neurodegeneration. Through the studies of in vitro and in vivo experimental models of glaucoma and studies of human donor eyes, her laboratory has analyzed the signaling pathways of retinal ganglion cell death, neuron-glia interactions, and inflammatory responses. More recent studies of Dr. Tezel have defined distinct molecular responses of retinal ganglion cells and glial cells using quantitative mass spectrometry-based proteomics analysis techniques. Ongoing studies of her laboratory specifically focus on inflammation signaling and oxidative stress and pursue the profile of cell-specific proteomics alterations by functional testing of outcome molecules using specific pharmacological treatments or transgenic models. Her current work also includes the analysis of blood samples for glaucoma biomarker discovery through the proteomics/immuoproteomics approaches.
Neurobiology and Proteomics of Retinal Ganglion Cells Cellular and Molecular Mechanisms of Glaucomatous Neurodegeneration Retinal Ganglion Cell/Glia Interactions Immunomodulation and Neuroprotection in Glaucoma Molecular Biomarkers of Glaucoma