William G. KaelinÂ
ProfessorÂ
Tumor
Dana-Farber Cancer Institute
United States of America
Biography
Dr. Kaelin received his MD from Duke University in 1982 and was a house officer and chief resident in internal medicine at Johns Hopkins Hospital. He was a medical oncology clinical fellow at Dana-Farber and a postdoctoral fellow in the laboratory of Dr. David Livingston, where he began his studies of tumor suppressor proteins. He became an independent investigator at Dana-Farber in 1992, and a Howard Hughes Medical Institute Investigator and Professor of Medicine at Harvard Medical School in 2002.
Research Interest
Tumor
Publications
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Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA et al (2016) Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell 1 :126-39.
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Gao W, Li W, Xiao T, Liu XS and Kaelin WG Jr (2017) Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. Proc Natl Acad Sci 5 :1027-1032.
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Chakraborty AA, Nakamura E, Qi J, Creech A, Jaffe JD et al (2017) HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase. Sci Transl Med.
