Alexey Glukhov

Biography

Dr. Alexey Glukhov graduated in Biophysics from the Moscow Institute of Physics and Technology, Russia, in 2003. He then moved to the laboratory of cardiac electrophysiology, Cardiology Research Centre, Moscow, to undertake a PhD studying the electrophysiological mechanisms of natural resistance of hibernating animals to ventricular arrhythmias associated with hypothermia and/or ischemia. After completing PhD, Dr. Glukhov has been trained at Washington University in Saint Louis, USA, and at the Ohio State University, USA, pursuing research at the interface between cardiac physiology/cell biology and biomedical engineering. In 2012, Alexey joined the laboratory of functional microscopy at Imperial College London, United Kingdom. He is currently an Assistant Professor in the Department of Medicine. Dr. Glukhov’s research focuses on understanding the multicellular mechanisms involved in cardiac remodeling following heart failure and atrial fibrillation among multiple levels of cardiac signaling: from protein expression, phosphorylation, and sub-cellular localization, protein-protein interaction, to propagation and repolarization of an intact heart. His research combines several state-of-the-art techniques, including high-resolution fluorescent optical mapping and scanning ion conductance microscopy (SICM) equipped with “smart” patch-clamp. These are applied to investigate sub-cellular compartmentalization of ion channels and regulatory G-protein coupled receptors and their roles in atrial and ventricular arrhythmogenesis/dysfunction associated with different pathologies.

Research Interest

cardiac remodeling following heart failure and atrial fibrillation among multiple levels of cardiac signaling: from protein expression, phosphorylation, and sub-cellular localization, protein-protein interaction, to propagation and repolarization of an intact heart.