Adrian Shieh
Associate Teaching ProfessorÂ
School of Biomedical Engineering, Science & Health Systems
Drexel University
United States of America
Biography
Dr. Adrian Shieh received his BSE in Bioengineering from the University of Pennsylvania in 2000. From 2000 to 2006, he conducted his PhD research in Bioengineering at Rice University with Prof. Kyriacos Athanasiou, studying how single chondrocytes responded to mechanical forces. From 2006 until 2010, he was conducting post-doctoral research at the École Polytechnique Fédérale de Lausanne in Lausanne, Switzerland, working with Prof. Melody Swartz to better understand the role of tumor-fibroblast interactions and fluid flow on invasive tumor behavior. Since joining Drexel, Dr. Shieh’s focus has been on elucidating the molecular mechanisms underlying how cancer cells respond to interstitial fluid flow.
Research Interest
3-D cell culture, cancer, cell and tissue engineering, extracellular matrix, fibroblasts, interstitial flow, mechanobiology, mechanotransduction, tumor invasion and metastasis, tumor microenvironment
Publications
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Tchafa AM, Ta M, Reginato MJ, Shieh AC. EMT transition alters interstitial fluid flow-induced signaling in ERBB2-positive breast cancer cells. Molecular Cancer Research 13(4):755-764, 2015.
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Munson JM, Shieh AC. Interstitial fluid flow in cancer: implications for disease progression and treatment. Cancer Management Research 6:317-328, 2015
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Shah AD, Bouchard MJ, Shieh AC. Interstitial fluid flow increases hepatocellular carcinoma cell invasion through CXCR4/CXCL12 and MEK/ERK signaling. PLOS One 10(11):e0142337, 2015.
