Pharmaceutical Sciences
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Pharmaceutical Sciences Experts

Aleem Gangjee

Professor
School of Pharmacy
Duquesne University
United States of America

Aleem Gangjee

Biography

Aleem Gangjee is working as professor at School of Pharmacy, Duquesne University. His area of research interest include Synthetic medicinal chemistry, computer-assisted drug design, inhibitors of folate metabolizing enzymes, receptor tyrosine kinase inhibitors, antimitotic agents, antitumor agents, antiopportunistic infection agents, nucleosides, heterocyclic chemistry and stereochemistry. Prof. Aleem Gangjee holds Ph.D.in Medicinal Chemistry, University of Iowa, 1975.

Research Interest

Synthetic medicinal chemistry, computer-assisted drug design, inhibitors of folate metabolizing enzymes, receptor tyrosine kinase inhibitors, antimitotic agents, antitumor agents, antiopportunistic infection agents, nucleosides, heterocyclic chemistry and stereochemistry.

Publications

  • Hou, Z.; Gattoc, L.; O'Connor, C.; Yang, S.; Wallace-Povirk, A.; George, C.; Orr, S.; Polin, L.; White, K.; Kushner, J.; Morris, R. T.; Gangjee, A. and Matherly, L. H. Dual Targeting of Epithelial Ovarian Cancer via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates. Mol. Cancer. Ther., 2017. Epub ahead of print. Doi: 10.1158/1535-7163.MCT-16-0444.

  • Zaware, N.; Kisliuk, R.; Bastian, A.; Ihnat, M. A. and Gangjee, A. Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents. Bioorg. Med. Chem. Letts., 2017, 27, 1602-1607

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