Larry J. Anderson, Md
United States of America
Larry J. Anderson, MD joined the Division of Pediatric Infectious Disease, Emory University School of Medicine as Professor and Marcus Chair of Infectious Diseases in 2010 after 33 years at the Centers for Disease Control and Prevention (CDC). His laboratory is focused on studies of the pathogenesis of respiratory syncytial virus (RSV) to guide vaccine development and the asthmatic immune response to RSV and rhinovirus to identify novel approaches to treating asthma exacerbations.
Pathogenesis of Respiratory Syncytial Virus (RSV) Disease: Our laboratory is focusing on pathogenesis of respiratory syncytial virus (RSV) disease to support development of vaccines and anti-viral treatment. RSV is the single most important cause of serious lower respiratory tract disease in the infant and young children and a high priority for vaccine development. Unfortunately, efforts to develop RSV vaccines have failed. Our laboratory is using the BALB/c mouse model and human airway epithelial cell lines plus human peripheral blood mononuclear cell (PBMC) cell culture system to explore virus induced host responses that contribute to disease and ways to prevent these responses. For the last 10 years, we have focused much of this work on the RSV G protein and its CX3C chemokine motif. The G protein and this motif appear to contribute to induction of a Th-2 type T cell response and enhanced pulmonary inflammatory after RSV infection and FI-RSV vaccination. For example, administration of a monoclonal antibody that bind G near the CX3C motif and blocks binding to CX3CR1 before or after challenge decreases the pulmonary inflammatory response in naïve or FI-RSV vaccinated mice. A G peptide vaccine that induces antibodies that block binding to CX3CR1 also blocks the Th2-type pulmonary inflammatory response seen after RSV challenge in FI-RSV vaccinated mice. We are using G peptide vaccines, anti-G monoclonal antibodies, clinical RSV isolates with different disease manifestations in mice, and genetically engineered viruses to 1) understand pathogenesis of RSV disease and especially that associated with the G protein and the CX3C motif on G and 2) develop novel approaches to making a safe and effective RSV vaccine.