Frederick Kauffman
Professor Emeritus
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Biochemical Pharmacology and Toxicology. A major focus of work has been to define events regulating the metabolism of drugs and foreign chemicals in intact cells and tissues. Emphasis has been directed primarily at the metabolism of biologically active compounds via Phase II conjugation reactions. Recent research projects include: identifying isoforms of sulfotransferase and sulfatase in neural tissue, and investigating their possible involvement in modulating levels and activities of neuorsteroids in the central nervous system; and, secondly using a unique model of estrogen-dependent mammary tumors in ACI rats to explore relationships between the metabolism of estradiol and the occurrence and progression of hormone-dependent breast tumors.
Research Interest
Toxicology
Publications
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Sanchez, RI, Mesia-Vela, S, Kauffman, FC. Induction of NAD(P)H quinone oxidoreductase and glutathione S-transferase activities in livers of female August-Copenhagen Irish rats treated chronically with estradiol: comparison with the Sprague-Dawley rat. J. Steroid Biochem. Mol. Biol. 2003;87 (2-3):199-206. . PubMed PMID:14672740
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Kauffman, FC. Sulfonation in pharmacology and toxicology. Drug Metab. Rev. 2004;36 (3-4):823-43. doi: 10.1081/DMR-200033496. PubMed PMID:15554249
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Mesia-Vela, S, Sanchez, RI, Reuhl, KR, Conney, AH, Kauffman, FC. Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish rat. J. Pharmacol. Exp. Ther. 2006;317 (2):590-7. doi: 10.1124/jpet.105.096867. PubMed PMID:16421288
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Stakhiv, TM, Mesia-Vela, S, Kauffman, FC. Phase II antioxidant enzyme activities in brain of male and female ACI rats treated chronically with estradiol. Brain Res. 2006;1104 (1):80-91. doi: 10.1016/j.brainres.2006.05.093. PubMed PMID:16822482
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Mesia-Vela, S, Sanchez, RI, Roberts, KG, Reuhl, KR, Conney, AH, Kauffman, FC. Dietary clofibrate stimulates the formation and size of estradiol-induced breast tumors in female August-Copenhagen Irish (ACI) rats. Toxicology. 2008;246 (1):63-72. doi: 10.1016/j.tox.2007.12.025. PubMed PMID:18280627 PubMed Central PMC2441444
