Guofeng You
Distinguished Professor
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
Research Interest
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporter
Publications
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Toh, MF, Suh, W, Wang, H, Zhou, P, Hu, L, You, G. Inhibitory effects of chemotherapeutics on human organic anion transporter hOAT4. Int J Biochem Mol Biol. 2016;7 (1):11-8. . PubMed PMID:27335682 PubMed Central PMC4913227
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Xu, D, Huang, H, Toh, MF, You, G. Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter. Int J Biochem Mol Biol. 2016;7 (1):19-26. . PubMed PMID:27335683 PubMed Central PMC4913228
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Xu, D, You, G. Rethinking the regulation of l-carnitine transport in skeletal muscle cells. Focus on "Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes". Am. J. Physiol., Cell Physiol. 2017;312 (6):C687-C688. doi: 10.1152/ajpcell.00093.2017. PubMed PMID:28424167 PubMed Central PMC5494588
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Xu, D, Zhang, J, Zhang, Q, Fan, Y, Liu, C, You, G. PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1. Drug Metab. Dispos. 2017;45 (8):887-895. doi: 10.1124/dmd.117.075861. PubMed PMID:28572241 PubMed Central PMC5506456
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Wang, H, You, G. SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3. Biopharm Drug Dispos. 2017; :. doi: 10.1002/bdd.2085. PubMed PMID:28608480
