Helmut Zarbl
Professor
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Dr. Zarbl serves as the Director of the NIEHS sponsored Center for Environmental Exposures and Disease. He is also the Associate Director For Public Health Sciences at the Cancer Institute of New Jersey. He serves on numerous national research review and advisory panels, and editorial panels.. Dr. Zarbl is known for his work in areas of toxicogenomics, and mechanisms of and genetic susceptibility to chemical carcinogenesis, mechanisms of mutagenesis and toxicity, and technology development. These research efforts have to date resulted in over 70 scientific papers and book chapters.
Research Interest
Toxicology
Publications
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Fang, M, Guo, WR, Park, Y, Kang, HG, Zarbl, H. Enhancement of NADâº-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. Oncotarget. 2015;6 (40):42879-91. doi: 10.18632/oncotarget.6002. PubMed PMID:26544624 PubMed Central PMC4767478
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Klaene, JJ, Flarakos, C, Glick, J, Barret, JT, Zarbl, H, Vouros, P. Tracking matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons. J Chromatogr A. 2016;1439 :112-23. doi: 10.1016/j.chroma.2015.10.057. PubMed PMID:26607319 PubMed Central PMC4789121
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Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
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Fang, M, Ohman Strickland, PA, Kang, HG, Zarbl, H. Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis. Oncotarget. 2017;8 (20):32752-32768. doi: 10.18632/oncotarget.15678. PubMed PMID:28427145 PubMed Central PMC5464825
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Green, AL, Zhan, L, Eid, A, Zarbl, H, Guo, GL, Richardson, JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017;125 :189-196. doi: 10.1016/j.neuropharm.2017.07.020. PubMed PMID:28743636
