Jeehiun Katherine Lee
Professor
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Our laboratory is multi-disciplinary, with projects that range from organic to biological to analytical. Recent projects include: (i) exploring how damaged DNA differs from normal DNA. Mutated bases are linked to carcinogenesis and cell death and it is therefore important to understand how these damaged bases differ from normal bases. In particular, we are interested in how the damaged bases are identified and excised by enzymes; (ii) identification of small RNAs in cell lysates (collaborative project); (iii) studying the properties of silanols, particularly acidity, to characterize their potential as catalysts (collaborative project); (iv) examining the properties and reactivities of N-heterocyclic carbenes, which are a “hot” topic nowadays due to their versatility (as organometallic ligands, organocatalysts, components in environmentally friendly solvents). Our methods include traditional organic tools (including synthesis) as well as spectroscopy (mass spectrometry, UV absorbance, NMR), and computational chemistry.
Research Interest
Toxicology
Publications
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Chen, M, Lee, JK. Computational studies of the gas-phase thermochemical properties of modified nucleobases. J. Org. Chem. 2014;79 (23):11295-300. doi: 10.1021/jo502058w. PubMed PMID:25379876
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Tian, Y, Lee, JK. Gas Phase Studies of N-Heterocyclic Carbene-Catalyzed Condensation Reactions. J. Org. Chem. 2015;80 (13):6831-8. doi: 10.1021/acs.joc.5b01069. PubMed PMID:26066314
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Teator, AJ, Tian, Y, Chen, M, Lee, JK, Bielawski, CW. An Isolable, Photoswitchable N-Heterocyclic Carbene: On-Demand Reversible Ammonia Activation. Angew. Chem. Int. Ed. Engl. 2015;54 (39):11559-63. doi: 10.1002/anie.201506269. PubMed PMID:26274507
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Kiruba, GS, Xu, J, Zelikson, V, Lee, JK. Gas-Phase Studies of Formamidopyrimidine Glycosylase (Fpg) Substrates. Chemistry. 2016;22 (11):3881-90. doi: 10.1002/chem.201505003. PubMed PMID:26894440
