Patrick Sinko
Distinguished Professor and Associate Vice Preside
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Dr. Sinko’s research is focused on the mechanisms and applications of biopharmaceutics and polymers to drug delivery and targeting. His laboratory is located in the Ernest Mario School of Pharmacy. His group’s research efforts focus on the design, fabrication and evaluation of molecular-scale drug and diagnostic delivery technologies applied broadly to asthma, AIDS, cancer, and chemical counterterrorism. Dr. Sinko’s research efforts have been continuously supported by the National Institutes of Health, various nonprofit organizations and the Pharmaceutical and Biotech industries. The research group is organized into therapeutic areas focusing on AIDS, cancer, and chemical counter-terrorism. Drug delivery at the molecular scale (i.e., nano) using biodegradable and biocompatible polymer platforms is a central theme. The scope of current projects includes a molecular mechanistic component, chemical design and synthesis, and biological and efficacy characterization (in vitro, in situ, and in vivo) with an emphasis on translation from concept to clinic.
Research Interest
chemical counterterrorism, biomaterials, hydrogels and nanocarriers
Publications
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Nelson, AG, Zhang, X, Ganapathi, U, Szekely, Z, Flexner, CW, Owen, A, Sinko, PJ. Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment. J Control Release. 2015;219 :669-80. doi: 10.1016/j.jconrel.2015.08.042. PubMed PMID:26315816 PubMed Central PMC4879940
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Gao, Y, Jin, B, Shen, W, Sinko, PJ, Xie, X, Zhang, H, Jia, L. China and the United States--Global partners, competitors and collaborators in nanotechnology development. Nanomedicine. 2016;12 (1):13-9. doi: 10.1016/j.nano.2015.09.007. PubMed PMID:26427355
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Samizadeh, M, Zhang, X, Gunaseelan, S, Nelson, AG, Palombo, MS, Myers, DR, Singh, Y, Ganapathi, U, Szekely, Z, Sinko, PJ et al.. Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates--proof of concept for HIV mucosal pre-exposure prophylaxis. Drug Deliv Transl Res. 2016;6 (1):1-16. doi: 10.1007/s13346-015-0269-4. PubMed PMID:26712122 PubMed Central PMC4736156
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Gao, Y, Gu, S, Zhang, Y, Xie, X, Yu, T, Lu, Y, Zhu, Y, Chen, W, Zhang, H, Dong, H et al.. The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention. Small. 2016;12 (19):2595-608. doi: 10.1002/smll.201600550. PubMed PMID:27027489
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Dong, H, Ma, J, Wang, J, Wu, ZS, Sinko, PJ, Jia, L. A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells. Mol Ther Nucleic Acids. 2016;5 :e302. doi: 10.1038/mtna.2016.18. PubMed PMID:27045206 PubMed Central PMC5014519
