William J Welsh
Professor in Bioinformatics and Molecular Design
Exposure Science
Environmental and Occupational Health Sciences Institute
United States of America
Biography
Dr. Welsh’s laboratory specializes in the development and application of computational tools for pharmaceutical drug discovery, predictive toxicology, and multi-dimensional pattern recognition. His laboratory’s interests extend to the molecular design and modeling of synthetic polymers, protein-material interactions, and protein-ligand interactions. In recent years, his laboratory has participated in the discovery of potential drug candidates for the treatment cancer, severe and chronic pain, and infectious diseases.
Research Interest
Exposure science
Publications
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Diller, DJ, Connell, ND, Welsh, WJ. Avalanche for shape and feature-based virtual screening with 3D alignment. J. Comput. Aided Mol. Des. 2015;29 (11):1015-24. doi: 10.1007/s10822-015-9875-y. PubMed PMID:26458937
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Zhang, Y, Li, Q, Welsh, WJ, Moghe, PV, Uhrich, KE. Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity. Biomaterials. 2016;84 :230-40. doi: 10.1016/j.biomaterials.2015.12.028. PubMed PMID:26828687 PubMed Central PMC4755878
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Groen, N, Guvendiren, M, Rabitz, H, Welsh, WJ, Kohn, J, de Boer, J. Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering. Acta Biomater. 2016;34 :133-142. doi: 10.1016/j.actbio.2016.02.015. PubMed PMID:26876875 PubMed Central PMC4830461
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Ai, N, Wood, RD, Yang, E, Welsh, WJ. Niclosamide is a Negative Allosteric Modulator of Group I Metabotropic Glutamate Receptors: Implications for Neuropathic Pain. Pharm. Res. 2016;33 (12):3044-3056. doi: 10.1007/s11095-016-2027-9. PubMed PMID:27631130
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Kimani, SG, Kumar, S, Bansal, N, Singh, K, Kholodovych, V, Comollo, T, Peng, Y, Kotenko, SV, Sarafianos, SG, Bertino, JR et al.. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017;7 :43908. doi: 10.1038/srep43908. PubMed PMID:28272423 PubMed Central PMC5341070
