Ercole Cavalieri

Biography

  Professor at Eppley Institute,Courtesy Professor, Dept of Environmental, Agricultural & Occupational Health College of Public Health  

Research Interest

 Molecular mechanisms of tumor initiation by polycyclic aromatic hydrocarbons (PAH) and estrogens. Origin of human cancer at the molecular level.  Prevention of cancer. This research includes: (a) in vitro and in vivo binding studies of estrogens to DNA, determination of the structure and quantitation of the adducts; (b) correlation of ras-oncogene mutations and formation of depurinating estrogen-DNA adducts; (c) mechanism of tumor initiation by catechol quinones of natural and synthetic estrogens; (d) analysis of biomarkers for the etiology and early detection of breast, prostate and other human cancers; (e) chemoprevention of human cancers by resveratrol, N-acetylcysteine and other compounds that reduce the formation of depurinating estrogen-DNA adducts.  .