Jixin Dong
Associate Professor
Cancer Research Program
Eppley Institute For Research
United States of America
Biography
He is working as an Asociate Professor, Eppley Institute
Research Interest
Research Interests Hippo signaling and Cancer Summary of Research My laboratory is focused on the Hippo signaling pathway, a novel tumor suppressor cascade discovered in Drosophila. Recent studies have demonstrated that the Hippo signaling plays an important role in controlling organ size by coordination of cell proliferation and cell death or apoptosis. The Hippo signaling pathway is highly conserved in mammals and consists of five core components: tumor suppressors Hippo/Hpo (human MST1/2), Salvador/Sav (human WW45), Warts/Wts (human Lats1/2), Mob as tumor suppressor/Mats (human Mob1) and oncoprotein Yorkie/Yki (human YAP). Hpo/MST phosphorylates and activates Wts/Lats, which in turn, inactivates Yki/YAP by phosphorylating them at a critical residue (Yki-S168/YAP-S127). Specifically, we are interested in how the Hippo pathway is regulated in mitosis and its subsequent biological significance in contributing to cancer development.
