Tahir Tahirov

Biography

  Professor at Eppley Institute

Research Interest

 Human genome contains all the information necessary to maintain and continue the life, and two basic processes are most important for that. One is a transcription of genetic information which leads to synthesis of proteins and another one is a replication and maintenance of the genomic information itself. Both of these processes are very complicated, involving large macromolecular machines and networks of highly coordinated events requiring protein-protein and protein-nucleic acid interactions. The disruptions in these events often lead to cancers and a variety of other diseases and disorders. The long term goal of our laboratory is to reveal the structural basis of the mechanisms covering the key stages in the expression and duplication/repair of genes and to learn how the disease-related mutations in proteins disrupt these key processes. Our research is based primarily on X-ray crystallography - the powerful method which provides the most precise three-dimensional structure of biological macromolecules.