Grimwade, Julia
Professor
Biological Sciences
Florida Institute of Technology
United States of America
Biography
Professor, Department of Biological Sciences, Florida Institute of Technology, 2007-present Research Committee Member, East Central Florida Memory Disorder Clinic, 2009-present Board of Directors, VNA of the Space Coast, 2014-present Associate Professor, Department of Biological Sciences, Florida Institute of Technology, 2000-2007 Assistant Professor, Department of Biological Sciences, Florida Institute of Technology, 1994-2000 Research Scientist, Department of Biological Sciences, Florida Institute of Technology, 1989-1994 NIH Post-Doctoral Fellow, Biology Department, University of Rochester, Rochester, NY 1987-1989
Research Interest
The research interest focuses on understanding molecular mechanisms that regulate bacterial growth. One ultimate goal of this research is to identify molecular targets that can be used to identify novel antibiotics.
Publications
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Rozgaja, T, Grimwade, J.E, , Iqbal, M., Czerwonka, C., Vora. M., and Leonard, A.C. (2011) Two oppositely-oriented arrays of low affinity recognition sites in oriC guide progressive binding of DnaA during E. coli pre-RC assembly, Mol. Microbiol., 82:475-488
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Leonard, A.C. and Grimwade, J.E. (2014) Chromosome replication and segregation, Reference Module in Biomedical Research, pp. 1-14, Elsevior.
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Kaur, G., Vora, M.P., Czerwonka, C.A., Rozgaja, T.A., Grimwade, J.E., and Leonard, A.C. (2014) Building the bacterial orisome: high-affinity DnaA recognition plays a role in setting the conformation of oriC DNA, Mol. Microbiol. 91:1148-1163.
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Saxena R., Vasudevan S., Patil D., Ashoura N., Grimwade J.E., and Crooke, E. (2015) Nucleotide-induced conformational changes in Escherichia coli DnaA protein are required for bacterial ORC to Pre-RC conversion at the chromosomal origin. IJMS 16:27897-27911
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Leonard, A.C., and Grimwade, J.E. (2015) The orisome: structure and function. Front. Microbiol. 6:545. doi: 10.3389/fmicb.2015.00545
