Guisbert, Eric
Assistant Professor
Biological Sciences
Florida Institute of Technology
United States of America
Biography
B.S., University of Michigan, highest honors, 1997 Ph.D., University of California, San Francisco 2006
Research Interest
Main research focus is the heat shock response. The heat shock response is a universal stress response that is also critical for normal growth and associated with a number of human diseases. The heat shock response activates a protective transcriptional program during sudden temperature increases, but it primarily senses protein misfolding and activates molecular chaperones that assist protein refolding.
Publications
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Guisbert E, Yura T, Rhodius VA, Gross CA. Convergence of molecular, modeling and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol Mol Biol Rev. 2008 Sep:72(3):545-54.
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Morimoto R, Prahlad V, Ben-Zvi A, Gidalevitz T, Westerheide S, Anckar J, Sistonen L, Guisbert E, Czyz D, Voisine C, Silva C, Beam M. Restoring Proteostasis via Chaperone Networks in Ageing and Neurodegenerative Disease. FASEB J. 2009 Apr, 23;91.1.
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Guisbert E, Morimoto RI. Regulation and Function of the Heat Shock Response. Protein Quality Control in Neurodegenerative Diseases. 2013. Springer. p 1-18.
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Guisbert E*, Czyz DM*, Richter K*, McMullen PD, Morimoto RI. Identification of a Tissue-selective Heat Shock Response Regulatory Network. PLOS Genetics. 2013 Apr;9(4):e1003466.
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Pedrosa Nunes K, Guisbert E, Szasz T, Webb C. The Innate Immune System Via Toll-Like Receptors (TLRs) in Type 1 Diabetes – Mechanistic Insights. Major Topics in Type 1 Diabetes. 2015. Intech. p 1-20.
