Leonard, Alan
Professor
Biological Sciences
Florida Institute of Technology
United States of America
Biography
B.S. Baldwin-Wallace College 1975 Ph.D. State University of New York, Buffalo 1979
Research Interest
His research is directed toward understanding the complex molecular machinery that regulates cell growth. Members of my lab are focused on studying the DNA–protein interactions and molecular assemblies that must take place during the cell cycle to ensure efficient duplication of the cell’s genome. Our fascination with these cellular machines is based on the remarkable temporal precision with which they are assembled and disassembled. Since many of the fundamental molecular cell growth mechanisms found in E. coli are shared by all cells, we hope that what we learn help to advance the areas of human cell growth and cancer.
Publications
-
Rozgaja, T, Grimwade, J, Iqbal, M., Czerwonka, C., Vora. M., and Leonard, A. 2011. Two oppositely-oriented arrays of low affinity recognition sites in oriC guide progressive binding of DnaA during E. coli pre-RC assembly. Mol. Microbiol., 82: 475-488.
-
Leonard, A.C., and Mechali, M. (2013) DNA Replication Origins. In S.D. Bell, M. Mechali, and M. DePamphilis, (eds.), DNA Replication, Cold Spring Harbor Laboratory Press 5(10) a010116. doi: 10.1101/cshperspect.a010116.
-
Kaur, G., Vora, M.P., Czerwonka, C.A., Rozgaja, T.A., Grimwade, J.E., and Leonard, A.C. (2014) Building the bacterial orisome: high-affinity DnaA recognition plays a role in setting the conformation of oriC DNA, Mol. Microbiol. 91:1148-1163.
-
Leonard, A.C., and Grimwade, J.E. (2015) The orisome: structure and function. Front. Microbiol. 6:545. doi: 10.3389/fmicb.2015.00545
