Moore, Lisa
Research Professor
Biological Sciences
Florida Institute of Technology
United States of America
Biography
Ph.D. Physiology University of Arizona 1993 MS Zoology Arizona State University 1987 BS, Biology Arizona State University 1982
Research Interest
Researcher is interested in the role gap junction channels (specialized ion channels) play in the cardiovascular and visual systems. These channels play a crucial role in communication between cells in most tissues. Their presence in animal tissues is nearly ubiquitous. Their role in the cardiovascular system is critical in providing the heart the ability to generate and maintain a regular beat (rhythm) and ensures that the heart contracts uniformly in a syncytial manner as a “pump” In the blood vessels, these channels ensure that proper tone and responsiveness is maintained in the blood vessel wall to support blood pressure and response to signals (hormones and other released agents or medications) by aiding in the arteriole smooth muscle relaxation or contraction. In the visual system, these channels provide an all-too-important function in accommodation of the retina to go from light to dark (as in daylight to dusk) situations. Essentially, these channels provide a way of increasing the signal-to-noise ratio or “turning up the gain” to process a visual image under low light situations.
Publications
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Moreau, V., Novak, M. J., and L. K. Moore. 2006. Effect of adrenalin, adrenochrome, and adrenolutin on connexin proteins in the cardiovasculature. Tox. Mech. and Meth. 16:373-377.
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Moore, L.K. and D.C. Spray. 1995. Gap junction single channel analysis in teleost horizontal cells suggests presence of multiple channel types. J. Inv. Opthm. & Vis. Sci. 36: 4 S602.
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Christ, G.C., D.C. Spray, M. El-Sabban, L.K. Moore and P.R. Brink. 1996. Gap junctions in vascular tissues: Evaluating the role of intercellular communication in the modulation of vasomotor tone. Circ. Res. 79 (4): 631646.
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Moreau, V., Novak, M. J., and L. K. Moore. 2006. Effect of adrenalin, adrenochrome, and adrenolutin on connexin proteins in the cardiovasculature. Tox. Mech. and Meth. 16:373-377.
