Rokach, Joshua
Professor
Chemistry
Florida Institute of Technology
United States of America
Biography
M.S. The Hebrew University Ph.D. Weizmann Institute of Science
Research Interest
Dr. Rokach’s main research interest is the use of bioorganic and synthetic chemistry to advance the understanding of biochemical and biological systems. The total syntheses of biologically important molecules are performed, and from these molecules, synthetic probes are designed to identify and isolate enzymes and receptors that have escaped isolation by the most commonly used techniques. Dr. Rokach’s other interests include discovery of new synthetic reactions, elucidation of reaction mechanisms, and synthesis of radioactive and other labeled molecules for the elucidation of biochemical pathways of the human body responsible for the generation of important mediators (hormones).
Publications
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"Two Potent OXE-R Antagonists: Assignment of Stereochemistry." P. Patel, C. N. Reddy, V. Gore, S. Chourey, Q. Ye, Y. P. Ouedraogo, S. Gravel, W. S. Powell, and J. Rokach. ACS Medicinal Chemistry Letters, 5, 815-819 (2014).
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"Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes." C.Cossette, S. Gravel, C. N. Reddy, V. Gore, S. Chourey, Q. Ye, N. W. Snyder, C. A. Mesaros, I. A. Blair, J-P. Lavoie, C. R. Reinero, J. Rokach, and W. S. Powell. Biochemical Pharmacology, 96, 247-255 (2015).
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"Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid." W. S. Powell and J. Rokach. Biochimica et Biophysica Acta (BBA), 1851, 340-355 (2015).
