Xu, Shaohua
Associate Professor
Biological Sciences
Florida Institute of Technology
United States of America
Biography
Ph.D. Purdue University 1989 BS Nanjing University, China 1983
Research Interest
We are interested in applying theories and methods developed in physics and chemistry to the understanding of biomedical problems at the molecular level. We focus on the structural analysis of single molecules, the process of molecular assembly and aggregation, and the surface and interface phenomenon in biology. We are also interested in developing methods for imaging animal tissues with the highest structural resolution and molecular recognition. Such information is often found to be critical in the elucidation of a protein’s biological function and role in the pathogenesis of a medical disease.
Publications
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Woodard D, Bell D, Tipton D, Durrance S, Cole L, Bin Li, Shaohua Xu. Gel Formation in Protein Amyloid Aggregation: A Physical Mechanism for Cytotoxicity. PLoS ONE 9(4): e94789, 2014.
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Wang, R Wang, R., Wang, H, Carrera, I, Xu, S., Lakshmana, M COPS5 Protein Overexpression Increases Amyloid Plaque Burden, Decreases Spinophilin-immunoreactive Puncta, and Exacerbates Learning and Memory Deficits in the Mouse Brain J. Biol. Chem. 290(14) 9299-9309 2015
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Wang, H Wang, Hongjie; Wang, Ruizhi; Xu, Shaohua; Lakshmana, Madepalli K. Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains. Neuroscience journal 2016 47328-37 2016
