Chambers, Jeremy Wayne
Assistant Professo
Cellular Biology and Pharmacology
Florida International University
United States of America
Biography
His graduate research was concerned with understanding the biochemistry of two hexokinase isoforms from the human pathogen Trypanosoma brucei. My research was published in the Journal of Biological Chemistry and Biochemical and Biophysical Research Communications. I also examined existing therapeutics for trypanocidal activities to use as treatments for African Sleeping Sickness. This work was published in Molecular and Biochemical Parasitology and Experimental Parasitology. Activities and Societies: Genetics and Biochemistry Graduate Student Association American Society of Microbiology.In his first postdoctoral position, I investigated the changes in metabolism that accompanied human cytomegalovirus (HCMV) infection. My research found that HCMV infection increased glutamine metabolism during infection to maintain anaplerosis in the tricarboxylic acid cycle and to maintain a high level of ATP production. These findings were published in the Journal of Virology.
Research Interest
Metabolic Biochemistry, Enzymology, Instrumentation, Cell Biology, and Project Development and Management.
Publications
-
Chambers, JW, et al. Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1). ACS Chemical Biology. 6(8). (2011). 808-818.
-
Chambers JW, et al. Blocking c-jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-hydroxydopamine-induced Toxicity in vitro and in vivo. Journal of Biological Chemistry. 288(2). (2013). 1079-87.
-
Chambers JW, et al. Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats. Journal of Biological Chemistry. 288(6). (2013). 4000-11.
-
Prado, A, Petroianu, GA, Lorke, DE, and Chambers, JW. A Trivalent Approach for Determining In Vitro Toxicology: Examination of Oxime K027. Journal of Applied Toxicology. (Published Online May 22, 2014).
