Patrick L. Green
Professor
Department of Veterinary Biosciences
Food Animal Health Research Program, OARDC
United States of America
Biography
Patrick L. Green had done PhD (Oncology) from University of Wisconsin - McArdle Laboratory for Cancer Research and Post-doctoral from University of California Los Angeles. He was Assistant Professor at Vanderbilt University and Associate Professor at The Ohio State University. At present he is Director of Center for Retrovirus Research, The Ohio State University.
Research Interest
Molecular Pathogenesis of Human T-cell Leukemia Virus (HTLV) Molecular Biology of Retrovirus Replication T-cell Activation/Transformation
Publications
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Panfil AR, Al-Saleem J, Howard CM, Mates JM, Kwiek JJ, Baiocchi RA, Green PL:Protein arginine methyltransferase 5 is upregulated in HTLV-1-mediated T-cell transformation and selective inhibition alters viral gene expression and infected cell survival. Viruses 2015 8(1), 7; doi:10.3390/v8010007. PMCID:PMC4728567
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Kawatsuki A, Yasunaga J,Mitobe Y, Green PL, Matsuoka M: HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells. Oncogene 2016, 35(34):4509-4517. PMCID: PMC4959989
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Panfil AR, Dissinger NJ, Landes K, Fernandez S, Green PL: Functional Comparison of HBZ and the Related APH-2 Protein Provide Insight Into HTLV-1 Pathogenesis. J Virology, 2016 90(7):3760-72. doi: 10.1128/JVI.03113-15. PMCID:PMC4794683
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Panfil AR, Martinez MP, Ratner L, Green PL: Human T-cell leukemia virus-associated malignancy. Current Opinion in Virology, 2016, 20:40-46.
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Webb LM, Amici SA, Jablonski K, Savardekar H, Panfil AR, Li L, Zhou W, Peine K, Karkhanis V, Bachelder E, Ainslie K, Green PL, Li C, Baiocchi RA, Guerau-de-Arellano M: Protein arginine methyltransferase 5 (PRMT5) selective inhibitors suppress inflammatory T cell responses and experimental autoimmune encephalomyelitis. J Immunol. 2017 Jan 13. pii: 1601702. doi: 10.4049/jimmunol.1601702. [Epub ahead of print] PMID:28087667
