David Wiest
Department of Cancer Research
Fox Chase Cancer Center
United States of America
Biography
David Wiest,Educational Background :Postdoctoral training, Developmental Immunology, NIH, 1995 PhD, Immunology, Duke University, 1991 BS, Microbiology, Penn. State University, 1984 Honors & Awards :NCI Board of Scientific Counselors. Senior Research Excellence Award, Temple Translational Science Symposium. American Cancer Society Southeastern Pennsylvania Research Award. Bucks County Board of Associates Key to the Chapter Award. Elected to Henry Kunkel Society. Inspired Leadership Award. Member, Program Committee, American Association of Immunologists. Member Faculty of 1000, Leukocyte Development Section. Member, CMIB study section. Cancer Research Institute Fellow. Norman F. Conant Award for Excellence in Research.
Research Interest
T lymphocyte development and transformation Molecular basis for specification of the two major T lymphocyte lineages, αβ and γδ. Regulatory functions of the ribosomal protein Rpl22 in hematopoiesis, lymphoid development, and leukemogenesis. Using zebrafish to identify disease-causing genes in immunodeficient humans.
Publications
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Lee, S. Y., Coffey, F., Fahl, S. P., Peri, S., Rhodes, M., Cai, K. Q., ... & Kappes, D. J. (2014). Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity, 41(6), 934-946.
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Rao, S., Cai, K. Q., Stadanlick, J. E., Greenberg-Kushnir, N., Solanki-Patel, N., Lee, S. Y., ... & Wiest, D. L. (2016). Ribosomal protein Rpl22 controls the dissemination of T-cell lymphoma. Cancer research, 76(11), 3387-3396.
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Solanki, N. R., Stadanlick, J. E., Zhang, Y., Duc, A. C., Lee, S. Y., Lauritsen, J. P. H., ... & Wiest, D. L. (2016). Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling. The Journal of Immunology, 197(6), 2280-2289.
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Punwani, D., Zhang, Y., Yu, J., Cowan, M. J., Rana, S., Kwan, A., ... & Chellappan, A. (2016). Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B. New England Journal of Medicine, 375(22), 2165-2176.
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Ribosomal proteins Rpl22 and Rpl22l1 control morphogenesis by regulating pre-mRNA splicing.
