Eileen K. Jaffe
Department of Molecular Therapeutics
Fox Chase Cancer Center
United States of America
Biography
Eileen K. Jaffe,Educational Background: Postdoctoral, Chemistry/Enzymology, Harvard University, 1979-1981. PhD, Biochemistry, University of Pennsylvania, 1979. BS, Chemistry, State University New York, Cortland, 1975. Memberships: American Chemical Society 1975 - present. American Society for Biochemistry and Molecular Biology, 1986 - present. AAAS membership 1979 - present. Association for Women in Science 1982 - present.
Research Interest
Quaternary structure dynamics and the control of protein function. Morpheein model for protein allostery, for which the prototype is porphobilinogen synthase. Morpheein model for protein allostery, for which the prototype is porphobilinogen synthase.
Publications
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Ramirez, U. D., Nikonova, A. S., Liu, H., Pecherskaya, A., Lawrence, S. H., Serebriiskii, I. G., ... & Jaffe, E. K. (2015). Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC cancer, 15(1), 436.
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Arturo, E. C., Gupta, K., Héroux, A., Stith, L., Cross, P. J., Parker, E. J., ... & Jaffe, E. K. (2016). First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proceedings of the National Academy of Sciences, 113(9), 2394-2399.
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Jaffe, E. K. (2016). The Remarkable Character of Porphobilinogen Synthase. Accounts of chemical research, 49(11), 2509-2517.
