Jinhua Wu
Department of molecular Therapeutics
Fox Chase Cancer Center
United States of America
Biography
Jinhua Wu,Educational Background: PhD, Structural Biology, Purdue University, West Lafayette, IN, 2004 BS, Biology, University of Science and Technology of China, Hefei, China, 1997 Memberships: Health Research Formula Grant Award, Pennsylvania Department of Health 2015 Member, American Cancer Society 2014 . American Cancer Society Institutional Research Grant Pilot Project Award 2012. Member, Fox Chase Cancer Center Cell Signaling Group 2010 . Member, Fox Chase Cancer Center Head and Neck Keystone 2010 .
Research Interest
Structural and Functional studies of integrin signaling. Structural basis to the regulatory mechanisms of the inside-out integrin signaling. Structural and functional analyses of the MRL family proteins. Development of anti-talin inhibitors by structure-based computer-aided design.
Publications
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Chang, Y. C., Zhang, H., Franco-Barraza, J., Brennan, M. L., Patel, T., Cukierman, E., & Wu, J. (2014). Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling. Structure, 22(12), 1810-1820.
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Yang, J., Zhu, L., Zhang, H., Hirbawi, J., Fukuda, K., Dwivedi, P., ... & Qin, J. (2014). Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Nature communications, 5, 5880.
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Zhang, H., Chang, Y. C., Huang, Q., Brennan, M. L., & Wu, J. (2016). Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Structure, 24(5), 721-729.
