Joseph R. Testa
Department of Cancer Research
Fox Chase Cancer Center
United States of America
Biography
Joseph R. Testa Educational Background: Postdoctoral fellow, University of Chicago, Chicago, IL, 1976-1980 PhD, Biological Sciences, Fordham University, New York, NY, 1976 BS, MS, Biology, Southern Connecticut State University, New Haven, CT, 1973 Certifications: Diplomate (Clinical Cytogenetics), American Board of Medical Genetics, 1987 Founding Fellow PhD, American College of Medical Genetics & Genomics (FACMG), 1993 Honors & Awards: Pioneer Research Award, Mesothelioma Applied Research Foundation, 2013 Wagner Medal, International Mesothelioma Interest Group, 2012 Elected Fellow, American Association for the Advancement of Science, 2012 The Reimann Honor Award of the Fox Chase Cancer Center, 2011 Memberships: American Association for the Advancement of Science. American Association for Cancer Research. American College of Medical Genetics . American Society of Hematology.
Research Interest
Molecular biology of mesothelioma; AKT oncogenic activity. Use of genetically engineered mice to assess gene–environment interactions, the role of asbestos-induced inflammation in tumor development, and as preclinical models for selective drug targeting of cellular pathways underpinning human tumorigenesis.
Publications
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Altomare, D. A., Menges, C. W., Xu, J., Pei, J., Zhang, L., Tadevosyan, A., ... & Klein-Szanto, A. J. (2011). Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One, 6(4), e18828.
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Menges, C. W., Kadariya, Y., Altomare, D., Talarchek, J., Neumann-Domer, E., Wu, Y., ... & Klein-Szanto, A. J. (2014). Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53–miR-34a–c-Met axis. Cancer research, 74(4), 1261-1271.
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Xu, J., Kadariya, Y., Cheung, M., Pei, J., Talarchek, J., Sementino, E., ... & Peng, H. (2014). Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma. Cancer research, 74(16), 4388-4397.
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Shapiro, I. M., Kolev, V. N., Vidal, C. M., Kadariya, Y., Ring, J. E., Wright, Q., ... & Xu, Q. (2014). Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship. Science translational medicine, 6(237), 237ra68-237ra68.
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Cheung, M., Kadariya, Y., Talarchek, J., Pei, J., Ohar, J. A., Kayaleh, O. R., & Testa, J. R. (2015). Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene–environment interaction. Cancer letters, 369(2), 261-265.
