Mark Andrake
Department of Cancer research
Fox Chase Cancer Center
United States of America
Biography
Mark Andrake, Educational Background - Postdoctoral Fellow, Fox Chase Cancer Center, Philadelphia, PA 1994 PhD, Molecular Genetics, Medical University of South Carolina, Charleston, SC, 1991 BS, Biochemistry, Carnegie Mellon University, Pittsburgh, PA, 1982 Training, Advanced Proton Source, Argonne National Laboratory, Argonne, IL Honors & Awards Principal Investigator, Awarded Two SAXS General User Proposals with beam time, APS, Argonne National Labs, 2010 NIH Individual Postdoctoral National Research Service Award, 1992 NCI Postdoctoral Trainee Award, National Cancer Institute, 1991 First Prize, PhD Poster Presentation, MUSC Student Research Day, 1989 First Prize, PhD Oral Presentation, MUSC Student Research Day, 1988 Elected Student Representative, Medical University of South Carolina, 1986 Graduate Assistantship, Medical University of South Carolina, 1985 Member, Beta Beta Beta Biological Honor Society, 1981
Research Interest
Structure and biochemistry of retroviral integrases and other early events of retroviral infection. Early events of retroviral infection and the cellular proteins associated with pre-integration complexers. Biochemistry and multimerization of retroviral integrases. The structure of retroviral integrases as investigated by X-ray cruystallography, small angle X-ray scattering and various other biophysical and computational methods. Screening for and development of allosteric inhibitors of integrase function. Viral restriction by the host factor Daxx protein. Use of computational modeling methods to understand and target a variety of cancer related proteins.
Publications
-
Andrake, M. D., Ramcharan, J., Merkel, G., Zhao, X. Z., Burke, T. R., & Skalka, A. M. (2009). Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution. AIDS research and therapy, 6(1), 14.
-
Bojja, R. S., Andrake, M. D., Weigand, S., Merkel, G., Yarychkivska, O., Henderson, A., ... & Skalka, A. M. (2011). Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking. Journal of Biological Chemistry, 286(19), 17047-17059.
-
Katz, R. A., Merkel, G., Andrake, M. D., Roder, H., & Skalka, A. M. (2011). Retroviral integrases promote fraying of viral DNA ends. Journal of Biological Chemistry, 286(29), 25710-25718.
-
Peletskaya, E., Andrake, M., Gustchina, A., Merkel, G., Alexandratos, J., Zhou, D., ... & Potapov, V. (2011). Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis. PloS one, 6(12), e27751.
-
Bojja, R. S., Andrake, M. D., Merkel, G., Weigand, S., Dunbrack, R. L., & Skalka, A. M. (2013). Architecture and assembly of HIV integrase multimers in the absence of DNA substrates. Journal of Biological Chemistry, 288(10), 7373-7386.
