Siddharth Balachandran
Department of Pathology
Fox Chase Cancer Center
United States of America
Biography
Siddharth Balachandran Educational Background PhD, Immunology & Molecular Pathogenesis, Emory University, Atlanta, GA, 2001 BS, Chemistry, Angelo State University, San Angelo, TX, 1995 Honors & Awards :Early Research Investigator Award, Temple Translational Science Symposium, 2013 First Prize, Zubrod Annual Poster Competition, University of Miami, 2005
Research Interest
Mechanisms of innate-immune and inflammatory cell death. Dissecting the molecular mechanisms of RIPK 1/3-kinase driven cell death activated by viruses and cytokines. Exploring the roles of RIPK 1/3-driven cell death in resolving acute RNA virus infections. Exploiting cytokine- and inflammatory cell death for treatment of human malignancies.
Publications
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Haugh, K. A., Shalginskikh, N., Nogusa, S., Skalka, A. M., Katz, R. A., & Balachandran, S. (2014). The interferon-inducible antiviral protein Daxx is not essential for interferon-mediated protection against avian sarcoma virus. Virology journal, 11(1), 100.
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Najjar, M., Suebsuwong, C., Ray, S. S., Thapa, R. J., Maki, J. L., Nogusa, S., ... & Yuan, J. (2015). Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell reports, 10(11), 1850-1860.
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Nogusa, S., Thapa, R. J., Dillon, C. P., Liedmann, S., Oguin, T. H., Ingram, J. P., ... & Verbist, K. (2016). RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus. Cell host & microbe, 20(1), 13-24.
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Nogusa, S., Slifker, M. J., Ingram, J. P., Thapa, R. J., & Balachandran, S. (2016). RIPK3 is largely dispensable for RIG-I-like receptor-and type I interferon-driven transcriptional responses to influenza A virus in murine fibroblasts. PloS one, 11(7), e0158774.
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Najjar, M., Saleh, D., Zelic, M., Nogusa, S., Shah, S., Tai, A., ... & Whalen, M. J. (2016). RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by Toll-like receptor 4. Immunity, 45(1), 46-59.
