Stephen M. Sykes
Department of Cancer Research
Fox Chase Cancer Center
United States of America
Biography
Stephen M. Sykes,Educational Background: PhD, Cell and Molecular Biology, University of Pennsylvania, Philadelphia, PA, 2007 BS, Biochemistry, Mount Allison University, Sackville, NB, 2000 AAS, Biology, Ulster County Community College, Stone Ridge, NY, 1997. Honors & Awards : Junior Scholar, American Society of Hemotology, 2014-2016 Tosteson Postdoctoral Fellowship Award, 2011 Eugene Goldwasser Fellowship in Hematology, International Society of Hematology, 2011
Research Interest
Normal and Malignant Hematopoietic Stem and Progenitor Cells Defining the molecular circuitry that distinguishes leukemia stem and progenitor cells from their healthy counterparts. Identifying and targeting critical regulators of redox biology to overcome chemotherapy resistance in acute myeloid leukemia (AML). Targeting ER stress responses to treat certain genetic sub-types of AML.
Publications
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Sykes, S. M., Mellert, H. S., Holbert, M. A., Li, K., Marmorstein, R., Lane, W. S., & McMahon, S. B. (2006). Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Molecular cell, 24(6), 841-851.
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Lee, D., Sykes, S. M., Kalaitzidis, D., Lane, A. A., Kfoury, Y., Raaijmakers, M. H., ... & Scadden, D. T. (2014). Transmembrane inhibitor of RICTOR/mTORC2 in hematopoietic progenitors. Stem cell reports, 3(5), 832-840.
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Kalaitzidis, D., Sykes, S. M., Wang, Z., Punt, N., Tang, Y., Ragu, C., ... & Anastasiou, D. (2012). mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell stem cell, 11(3), 429-439.
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Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., ... & Armstrong, S. A. (2014). Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood, 124(1), 13-23.
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Sykes, S. M., Lane, S. W., Bullinger, L., Kalaitzidis, D., Yusuf, R., Saez, B., ... & Acharya, S. S. (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell, 146(5), 697-708.
