Warren D. Kruger
Department of Cancer Research
Fox Chase Cancer Center
United States of America
Biography
Warren D. Kruger, PhD Educational Background; BA, Biology, Cornell University, Ithaca, NY, 1985 PhD, Genetics, University of California at San Francisco, San Francisco, CA, 1991 Memberships : American Society of Human Genetics, 1990 American Association for the Advancement of Science, 1995 American Association for Cancer Research, 1997 Elected President of Fox Chase Cancer Center Faculty Senate, 2010 Society for Inherited Metabolic Disorders, 2011
Research Interest
Amino Acid Genetics and Human Disease. Mouse models with altered sulfur amino acid homeostasis. Proteostasis modulators and mutant CBS. Targeting MTAP deletion in human cancer. Alterations in blood amino acids in human cancer patients.
Publications
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Tang, B., Testa, J. R., & Kruger, W. D. (2012). Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer biology & therapy, 13(11), 1082-1090.
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Gupta, S., Melnyk, S. B., & Kruger, W. D. (2014). Cystathionine β-synthase-deficient mice thrive on a low-methionine diet. The FASEB Journal, 28(2), 781-790.
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Tang, B., Kadariya, Y., Chen, Y., Slifker, M., & Kruger, W. D. (2015). Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3: Genes, Genomes, Genetics, 5(1), 35-44.
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Lee, H. O., Mustafa, A., Hudes, G. R., & Kruger, W. D. (2015). Hydroxychloroquine destabilizes phospho-S6 in human renal carcinoma cells. PloS one, 10(7), e0131464.
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Gupta, S., Wang, L., & Kruger, W. D. (2016). Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. Journal of inherited metabolic disease, 39(1), 39-46.
