Johanna W. Lampe
Professor
Public Health
Fred Hutchinson Cancer Rearch Center
United States of America
Biography
Dr. Lampe is a Full Member and Associate Division Director in the Public Health Sciences Division at Fred Hutchinson Cancer Research Center and a Research Professor in the Department of Epidemiology at the University of Washington in Seattle. She received her PhD in nutritional sciences, with a minor in biochemistry, from the University of Minnesota and trained as a post-doctoral fellow in epidemiology at the University of Minnesota before joining the faculty at Fred Hutchinson Cancer Research Center in 1994. Dr. Lampe’s research focuses on the effect of diet constituents on cancer susceptibility in humans and the effects of genetic variation on response to diet. Her group uses controlled dietary interventions to evaluate cancer biomarker-response to diet and specific phytochemicals. In addition, her lab studies the modifying effects of the gut microbiome on phytochemical metabolism and disease risk. One of her current research projects, supported by the NIH and in collaboration with Drs Chapkin (TAMU) and Hullar (FHCRC), addresses the effects of bacterially-derived enterolignans on gut epithelial and stromal gene expression. Dr. Lampe is a member of the American Association for Cancer Research, the Academy of Nutrition and Dietetics, the American Society for Nutrition, and the Groupe Polyphénols. She is an elected member of the AACR Molecular Epidemiology Working Group Steering Committee.
Research Interest
Dr. Lampe's research interests relate to the mechanisms by which components of diet, particularly constituents of plant food, alter susceptibility to and risk of cancer. Her primary research activities include using controlled dietary interventions in humans to determine how individual variation in biochemical response to high-plant food diets (e.g., biotransformation enzyme modulation, colonic environment changes) may explain differences in disease risk. The Lampe lab also studies the effect of diet on gut microbial community and the relationship of the gut microbiome to biomarkers of cancer risk and routinely measures isoflavones, lignans, and other biomarkers of plant-food intake for population-based studies.
Publications
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Fu BC, Randolph TW, Lim U, Monroe KR, Cheng I, Wilkens LR, Le Marchand L, Hullar MAJ, Lampe JW. 2016. Characterization of the gut microbiome in epidemiologic studies: the multiethnic cohort experience.. Annals of epidemiology. 26(5):373-379
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Song X, Diep P, Schenk JM, Casper C, Orem J, Makhoul Z, Lampe JW, Neuhouser ML. 2016. Changes in relative and absolute concentrations of plasma phospholipid fatty acids observed in a randomized trial of Omega-3 fatty acids supplementation in Uganda.. Prostaglandins, leukotrienes, and essential fatty acids. 114:11-16
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Citronberg JS, Wilkens LR, Lim U, Hullar MAJ, White E, Newcomb PA, Le Marchand L, Lampe JW. 2016. Reliability of plasma lipopolysaccharide-binding protein (LBP) from repeated measures in healthy adults.. Cancer causes & control : CCC. 27(9):1163-1166.
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Song X, Schenk JM, Diep P, Murphy RA, Harris TB, Eiriksdottir G, Gudnason V, Casper C, Lampe JW, Neuhouser ML. 2016. Measurement of Circulating Phospholipid Fatty Acids: Association between Relative Weight Percentage and Absolute Concentrations.. Journal of the American College of Nutrition. 35(7):647-656
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Miller LM, Lampe JW, Newton KM, Gundersen G, Fuller S, Reed SD, Frankenfeld CL. 2017. Being overweight or obese is associated with harboring a gut microbial community not capable of metabolizing the soy isoflavone daidzein to O-desmethylangolensin in peri- and post-menopausal women.. Maturitas. 99:37-42.
