Sharp, Joshua
Adjunct Research Scientist
Department of Chemistry
Georgia University
United States of America
Biography
Dr. Sharp received his B.S. in Microbiology in 1999 from the University of Tennessee in Knoxville, and his Ph.D. in Genome Science and Technology in 2003 under the direction of Dr. Robert Hettich of the Chemical Sciences Division at Oak Ridge National Laboratory. Dr. Sharp performed his post-doctoral research at the National Institute of Environmental Health Sciences (NIH) in the laboratory of Dr. Kenneth Tomer, working on the development and application of protein chemistry coupled to mass spectrometry for probing the biophysical properties of large protein complexes of biomedical interest. Dr. Sharp joined the CCRC in 2007.
Research Interest
Combination of biological chemistry and mass spectrometry to address problems in protein structural characterization, protein modification by oxidative stress, and detailed structural analysis of sulfated glycosaminoglycans.
Publications
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Z. Liz, HA Moniz, A. Ramiah, KW Moremen, JS Sharp. 2015. High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo-1-Heparin Binding Interface. J. Biol. Chem. In press.
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C. Zong, R. Huang, E. Condac, Y Chiu, W.Y. Xiao, X. Li, W Lu, M Ishahara, S. Wang, A. Ramiah, M Stickney, P. Azadi, IJ Amster, KW Moremen, L. Wang, JS Sharp, GJ Boons. 2016. Integrated approach to identify heparan sulfate ligand requirements of Robo1. J Am Chem Soc 138(39): 13059- 13067.
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R Huang, C Zong, A Venot, Y Chiu, D Zhou, GJ Boons, JS Sharp. 2016. De novo sequencing of complex mixtures of heparan sulfate oligosaccharides. Anal Chem 88(10): 5299-5307.
