Engineering Experts

John J. Heine

H. Lee Moffitt Cancer Center and Research Institute
United States of America


John J. Heine is an senior member at MOFFITT Cancer center. His education and training was done at University of South Florida, He had done his MS in department of Physics and phD on Engineering Science from University of South Florida.

Research Interest

Dr. Heine’s current research blends imaging physics with statistical learning methods to address unresolved issues in epidemiology with an emphasis on breast cancer risk assessments. Mammographic breast density is a significant breast cancer risk factor, not used clinically due to measurement difficulties. Dr. Heine has made significant inroads into developing methods of calibrating mammograms to adjust for the acquisition technique differences and developing automated measures of breast density that show strong association with breast cancer. In parallel, Dr Heine is developing novel methods of incorporating statistical learning techniques into epidemiology for improved risk modeling. The near term objective of this discipline fusion research is to develop an automated system for data collection and analysis to enable both population and individual level risk assessments at the breast clinics within Moffitt Cancer Center.


  • Lu B, Smallwood AM, Sellers TA, Drukteinis JS, Heine JJ, et al. (2015) Calibrated breast density methods for full field digital mammography: a system for serial quality control and inter-system generalization. Med Phys 42:623-636.

  • Liu Y, Wang H, Li Q, McGettigan MJ, Balagurunathan Y, Garcia AL, et al. (2017) Radiologic Features of Small Pulmonary Nodules and Lung Cancer Risk in the National Lung Screening Trial: A Nested Case-Control Study. Radiology.

  • Engmann NJ, Scott C, Jensen MR, Ma L, Brandt KR, et al. (2017) Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors. Cancer Epidemiol Biomarkers Prev 26:930-937.

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