Victor M. Navarro
Assistant Professor
Departmaent of Endocrinology
Harvard Medical School
United States of America
Biography
2007 - 2009 Fulbright Fellowship 2008 Endocrine Scholars Award 2009 - 2011 Marie Curie International Outgoing Fellowship 2010 The Endocrine Society Outstanding Abstract Award 2012 K99/R00 Pathway to Independence Award 2013 The Endocrine Society Outstanding Abstract Award 2013 Early Career Investigators Award 2013 Microgrant for Faculty Development 2014 Eugenia Rosemberg Abstract Award 2014 - 2015 Charles H. Hood Foundation Child Health Research Award Dr. Navarro is an Assistant Professor of Medicine at Harvard Medical School and Brigham and Women’s Hospital. He received his PhD from the University of Córdoba, Spain, in 2006 under the mentorship of Dr. Manuel Tena-Sempere. His dissertation work focused on the characterization of the neuroendocrine mechanisms that control reproductive function, with special emphasis on the role of kisspeptins in the attainment and maintenance of fertility. In 2007, Dr. Navarro joined the group of Dr. Robert A. Steiner at the University of Washington, Seattle. During this period (2007-2011), he studied the neuronal mechanisms that control kisspeptin release and proposed a model of interaction between neurokinin B, dynorphin and kisspeptin that has become accepted by his peers as the likely GnRH pulse generator. In 2012, Dr. Navarro was recruited to join the faculty of the Division of Endocrinology at Harvard Medical School and Brigham and Women’s Hospital, Boston, where he continues his research on the characterization of the central circuits governing reproductive function and metabolism.
Research Interest
The Kiss1 system in the neuroendocrine control of reproduction Endocrinology
Publications
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Roa J, Navarro VM, Tena-Sempere M. Kisspeptins in reproductive biology: consensus knowledge and recent developments. Biol Reprod. 2011 Oct; 85(4):650-60. PMID: 21677307.
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Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol. 2011 Sep 13; 8(1):40-53. PMID: 21912400.
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Navarro VM, Gottsch ML, Wu M, GarcÃa-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA. Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology. 2011 Nov; 152(11):4265-75. PMID: 21914775; PMCID: PMC3198996.
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GarcÃa-Galiano D, van Ingen Schenau D, Leon S, Krajnc-Franken MA, Manfredi-Lozano M, Romero-Ruiz A, Navarro VM, Gaytan F, van Noort PI, Pinilla L, Blomenröhr M, Tena-Sempere M. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012 Jan; 153(1):316-28. PMID: 22067321.
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Ruiz-Pino F, Navarro VM, Bentsen AH, Garcia-Galiano D, Sanchez-Garrido MA, Ciofi P, Steiner RA, Mikkelsen JD, Pinilla L, Tena-Sempere M. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology. 2012 Oct; 153(10):4818-29. PMID: 22822161; PMCID: PMC3512006.
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Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013; 784:325-47. PMID: 23550013; PMCID: PMC3858905.
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Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, Sánchez-Garrido MA, Leon S, Dieguez C, Cordido F, Matagne V, Dissen GA, Ojeda SR, Pinilla L, Tena-Sempere M. Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology. 2013 Feb; 154(2):942-55. PMID: 23291449; PMCID: PMC3548186.
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Popa SM, Moriyama RM, Caligioni CS, Yang JJ, Cho CM, Concepcion TL, Oakley AE, Lee IH, Sanz E, Amieux PS, Caraty A, Palmiter RD, Navarro VM, Chan YM, Seminara SB, Clifton DK, Steiner RA. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013 Aug; 154(8):2784-94. PMID: 23736293; PMCID: PMC3713212.
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Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27; 368(26):2467-75. PMID: 23738509; PMCID: PMC3808195.
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Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):335-41. PMID: 23807606; PMCID: PMC3898855.
