Peter Park
Scientist
Ludwig Center Harvard, Ludwig Institute for Cancer Research
Harvard University
United States of America
Biography
I am a computational biologist, specializing in epigenomics and cancer genomics, particularly the computational and statistical analysis of genomic data. We analyze epigenome and whole-genome sequencing datasets from cancer and other diseases, using high-throughput sequencing technology. My lab has participated in a number of important genomics initiatives, including the ENCODE project to profile histone modifications and chromatin-associated proteins, for which we led the cross-species (human-fly-worm) chromatin analysis for the consortium. We have also been involved in The Cancer Genome Atlas (TCGA) project, which has performed comprehensive genomic characterization of nearly 10,000 cancer samples. I originally trained in applied mathematics at Harvard and Caltech, and became interested in molecular biology and genomics during a postdoctoral fellowship at the Harvard School of Public Health. Today, I am an Associate Professor at Harvard Medical School, where I co-direct the doctoral program in Bioinformatics and Integrative Genomics. I live in Cambridge, Massachusetts, with my wife, who is on the piano faculty at the New England Conservatory Preparatory School, and spend most of my free time with my two beautiful children.
Research Interest
Epigenomics and cancer genomics, computational and statistical analysis of genomic data
Publications
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Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. The impact of environmental and endogenous damage on somatic mutation load in human skin fibroblasts.
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Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CWM. ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet 2017;49(2):296-302.
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Lee S*, Lee S*, Ouellette S, Park W-Y, Lee EA**, Park PJ**. NGSCheckMate: software for validating sample identity in next-generation sequencing studies within and across data types. Nucleic Acids Res 2017.
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Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, De Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, Zhang J, Yang L, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Westbrook TF, Shelley CS, Choueiri TK, Ittmann M, Van Waes C, Weinstein JN, Liang H, Henske EP, Godwin AK, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell 2017;31(6):820-832.e3.
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Cortes-Ciriano I*, Lee S*, Park W-Y, Kim T-M, Park PJ. A molecular portrait of microsatellite instability across multiple cancers. Nat Commun 2017;8:15180.
