Joseph Brain
Professor
Department of Environmental Health
Harward School Of Public Health
United States of America
Biography
S.D., 1966, Harvard T.H. Chan School of Public Health S.M., 1963, Harvard Paulson School of Engineering and Applied Sciences S.M., 1962, Harvard Paulson School of Engineering and Applied Sciences B.A., 1961, Taylor University
Research Interest
Dr. Brain’s research emphasizes responses to inhaled gases, particulates, and microbes. His studies extend from the deposition of inhaled particles in the respiratory tract to their clearance by respiratory defense mechanisms. Of particular interest is the role of lung macrophages; this resident cell keeps lung surfaces clean and sterile. Moreover, the lung macrophage is also a critical regulator of inflammatory and immune responses. The context of these studies on macrophages is the prevention and pathogenesis of environmental lung disease as well as respiratory infection.
Publications
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Molina RM and Brain JD. In vivo comparison of cat alveolar and pulmonary intravascular macrophages: phagocytosis, particle clearanc,e and cytoplasmic motility. Exp Lung Res. 2007; 33(2):53-70.
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Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD. Non-infectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor. PNAS. 2007; 104(12):5097-5102.
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Lichtenstein JHR, Molina RM, Donaghey TC, Brain JD. Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol. 2006; 35:415-23.
