Bradley R. Cairns
Professor
Department of Biochemistry
Huntsman Cancer Institute
United States of America
Biography
Dr. Cairns received his B.S. (Honors) in Chemistry from Lewis and Clark College in Portland, Oregon in 1987. He conducted his graduate work at Stanford with Nobel Laureate Roger Kornberg PhD on both signal transduction and chromatin remodeling. He received his PhD in Cell Biology from Stanford in 1996, and also conducted an early phase of postdoctoral training (funding from the American Cancer Society). Dr. Cairns received formal postdoctoral training with Fred Winston PhD in the Department of Genetics at Harvard Medical School (funding from the Leukemia Society of America), where he continued to study chromatin remodeling complexes. In 1998, he joined the faculty of the Department of Oncological Sciences and the Huntsman Cancer Institute. In 2000, he was appointed as an Investigator with the Howard Hughes Medical Institute. He is currently Professor and Chair of the Department of Oncological Sciences, and is the Jon and Karen Huntsman Presidential Professor of Cancer Research and Senior Director of Basic Science at the Huntsman Cancer Institute – both within the University of Utah, School of Medicine. He is Co-Leader of the Nuclear Control of Cell Growth and Differentiation Program.Research.
Research Interest
Cancer Biology DNA Methylation Zebrafish Transcription Factors Chromatin
Publications
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Oler AJ, Cairns BR (2012). PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. EMBO J, 31(6), 1440-52.
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Potok ME, Nix DA, Parnell TJ, Cairns BR (2013). Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell, 153(4), 759-72.
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Khoddami V, Cairns BR (2013). Identification of direct targets and modified bases of RNA cytosine methyltransferases. Nat Biotechnol, 31(5), 458-64.
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Hammoud SS, Low DH, Yi C, Carrell DT, Guccione E, Cairns BR (2014). Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis. Cell Stem Cell, 15(2), 239-53.
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Parnell T J, Schlicter A, Wilson B G, Cairns B R (Spring 2015). The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. eLife, 4, e06073.
