Danny Hung-chieh Chou
Professor
Department of Biochemistry, Pharmaceutics and Pharmaceutica
Huntsman Cancer Institute
United States of America
Biography
Danny Chou was born in I-lan, Taiwan and received his bachelor degree in Chemistry from National Taiwan University in 2006. From 2003 to 2006, he worked under the supervision of Prof. Ken-Tsung Wong and received trainings in organic synthesis. After a year of mandatory military service, he attended graduate school at Harvard University, working in the lab of Prof. Stuart Schreiber and Dr. Bridget Wagner. His Ph.D. research involved the identification of suppressors of cytokine-induced apoptosis in pancreatic beta cells. He then moved to MIT, where he was a JDRF Postdoctoral Fellow in Department of Chemical Engineering. He worked under the guidance of Profs. Robert Langer and Daniel Anderson, focusing on the development of glucose-responsive insulin derivatives. Danny started his independent career in Department of Biochemistry at University of Utah in August, 2014. At Utah, Danny's research focuses on protein and peptide therapeutics for the treatment in Type 1 Diabetes and other human diseases.
Research Interest
Pharmaceutics Biochemistry Pharmaceutical Chemistry
Publications
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Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK (2010). Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. ACS Chem Biol, 5(8), 729-34.
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Chou DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, Wagner BK (2012). Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chem Biol, 19(6), 669-73.
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Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dancik V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK (2015). Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. J Am Chem Soc, 137(24), 7929-34.
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Chou DH, Webber MJ, Tang BC, Lin AB, Thapa LS, Deng D, Truong JV, Cortinas AB, Langer R, Anderson DG (2015). Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. Proc Natl Acad Sci U S A, 112(8), 2401-6.
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Wang Y, Chou DH (2015). A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization. Angew Chem Int Ed Engl, 54(37), 10931-4.
