Dean Tantin
Professor
Department of Pathology
Huntsman Cancer Institute
United States of America
Biography
Dean Tantin is an Associate Professor in the Department of Pathology at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute. Tantin studies gene expression and its relationship to immune and stem cell function, and malignancy. He focuses on a class of transcription factors that have been tied to cellular reprogramming and immune function. The proteins are called Oct1, Oct2, and Oct4. These proteins affect cellular physiology and differentiation state through control of metabolism and through control of poised (silent but readily inducible) gene expression states. They interact with multiple cofactors that control local chromatin and gene expression. Tantin received a B.S. in Molecular Biology from the University of California, San Diego and a Ph.D. from the UCLA Molecular Biology Interdepartmental Ph.D. program. He was a Postdoctoral Fellow at the Massachusetts Institute of Technology Center for Cancer Reseach and Department of Biology under Nobel Laureate Phil Sharp.
Research Interest
Gene Regulation Development and Regulation of Immune Responses Stem Cells Transcriptional Control of Malignant State
Publications
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Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D (2015). Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med, 212(12), 2115-31.
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Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J (2016). Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.LID - 10.7554/eLife.17985 [doi]LID - e17985 [pii]. Elife, 5.
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Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D (2017). Enforcement of developmental lineage specificity by transcription factor Oct1.LID - 10.7554/eLife.20937 [doi]LID - e20937 [pii]. Elife, 6.
