Julie L. Kadrmas
Professor
Oncological Sciences
Huntsman Cancer Institute
United States of America
Biography
Julie Kadrmas, Ph.D. is an investigator in the Cell Response and Regulation Program at the Huntsman Cancer Institute. Her group is interested in understanding regulatory mechanisms controlling cell adhesion and migration, with implications for how cancer cells gain the capacity to leave the site of a primary tumor and migrate during metastasis. Through the examination of normal developmental processes in the fruit fly Drosophila melanogaster, they characterize the functions of the integrin family of transmembrane receptors in regulating cell attachment and movement. Of particular interest is a molecular scaffolding protein called PINCH, which physically associates with integrins, as well as several additional PINCH protein partners that impinge upon distinct signaling cascades. Their work will provide a molecular understanding of how protein-protein interactions mediated by molecular scaffolds such as PINCH, integrate signals between multiple pathways to coordinate complex biological processes like cell adhesion and migration.
Research Interest
Integrin Signaling Integrin Adhesion Cell Migration Metastasis Drosophila melanogaster
Publications
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Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle MC (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol, 167(6), 1019-24.
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Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
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Yoshigi M, Pronovost SM, Kadrmas JL (2013). Interactions by 2D Gel Electrophoresis Overlap (iGEO): a novel high fidelity approach to identify constituents of protein complexes. Proteome Sci, 11(1), 21.
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Clark KA, Kadrmas JL (2013). Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Cytoskeleton (Hoboken), 70(6), 304-16.
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Pronovost SM, Beckerle MC, Kadrmas JL (2013). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet, 9(3), e1003406.
